The Pamir Hayway start Mazari Sharif (Afghanistan), passes through Termiz (Uzbekistan) and crossing into Tajikistan. It then follows a general eastward route through Dushanbe to Khorog. From there, it continues east for about 310 kilometers to Murghab, where it crosses the Murghab River. The highway then passes through the 4,655-meter high Ak-Baital pass and past Lake Karakul before crossing into Kyrgyzstan.
We took a jeep from Murghab to Sary Tash (Kyrgyzstan).